XANTHOHUMOL RESEARCH
Xanthohumol is a natural flavonoid extracted from the hop. The beneficial activity of this compound in the human body is staggeringly broad.
Xanthohumol is an excellent antioxidant. It delays aging, increases vigor and is highly effective against fungi, bacteria, viruses and cancer.
ANTIOXIDANT
Xanthohumol is one of the strongest antioxidants known to mankind. It effectively protects humans and animals by eradicating the free radicals present in the body which impair cell membranes. The presence of free radicals in the body are the main cause of numerous serious diseases. Xanthohumol slows down the aging process and prevents many so-called “civilization diseases” – atherosclerosis, heart infarctions, strokes, cancers, diabetes, and age-related macular degenerations (AMD).
Scientific publications
Differential anti-inflammatory pathway by xanthohumol in IFN-gamma and LPS-activated macrophages
Y.C. Cho, H.J. Kim, Y.J. Kim, K.Y. Lee, H.J. Choi, I.S. Lee, B.Y. KangInternational Immunopharmacology, 8 (4) (2008), pp. 567–573
Angiogenesis and inflammation signaling are targets of beer polyphenols on vascular cells
R. Negrao, R. Costa, D. Duarte, T.T. Gomes, M. Mendanha, L. Moura, et al. Journal of Cellular Biochemistry, 111 (2010), pp. 1270–1279
Xanthohumol-Supplemented beer modulates angiogenesis and inflammation in a skin wound healing model
R. Negrao, R. Costa, D. Duarte, T.T. Gomes, P. Coelho, J.T. Guimaraes, et al. Involvement of local adipocytes, Journal of Cellular Biochemistry, 113 (2012), pp. 100–109
Antioxidant and prooxidant actions of prenylated and nonprenylated chalcones and flavanones in vitro
C.L. Miranda, J.F. Stevens, V. Ivanov, M. McCall, B. Frei, M.L. Deinzer, D.R. Buhler Journal of Agricultural and Food Chemistry, 48 (9) (2000), pp. 3876–3884
Synthesis, cytotoxicity, and antioxidative activity of minor prenylated chalcones from Humulus lupulus
Susanne Vogel and Jörg Heilmann Journal of Natural Products, 71(7), 1237-1241 (2008)
Antioxidant effects of xanthohumol and functional impact on hepatic ischemia-reperfusion injury. et.
Andreas Hartkorn Al Journal of Natural Products, 72(10), 1741-1747 (2009)
ANTICANCER
Xanthohumol stops or in some cases, reverses the process of Carcinogenesis (development of cancer). It indicates strong chemopreventive activity against prostate, breast, colon, and cervical cancer. Chemoprevention, contrary to chemotherapy, works even from the earliest stages of cancer formation.
Scientific publications
Enhanced antitumor activity of xanthohumol, a diacylglycerol acyltransferase inhibitor, under hypoxia
K. Goto, T. Asai, S. Hara, I. Namatame, H. Tomoda, M. Ikemoto, N. Oku Cancer Letters, 219 (2) (2005), pp. 215–222
Xanthohumol, prenylated flavonoid contained in beer, prevents the induction of preneoplastic lesions and DNA damage in liver and colon induced by the heterocyclic aromatic mine amino-3-methyl-imidazo(4,5-f)quinoline (IQ)
F. Ferk, W.W. Huber, B. Filipič, J. Bichler, E. Haslinger, M. Mišik, et al. Mutation Research, 691 (2010), pp. 17–22
Prenylated halcones and flavanones as inducers of quinine reductase in mouse Hepa 1c1c7 cells
C.L. Miranda, G.L. Aponso, J.F. Stevens, M.L. Deinzer, D.R. Buhler Cancer Letters, 149 (2000), pp. 21–29
Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines
C.L. Miranda, J.F. Stevens, A. Helmrich, M.C. Henderson, R.J. Rodriguez, Y.H. Yang, et al. Food and Chemical Toxicology, 37 (1999), pp. 271–285
Xanthohumol inhibits inflammatory factor production and angiogenesis in breast cancer xenografts
R. Monteiro, C. Calhau, A.O. Silva, S. Pinheiro-Silva, S. Guerreiro, F. Gartner, et al. Journal of Cellular Biochemistry, 104 (5) (2008), pp. 1699–1707
Cancer hemopreventive activity of xanthohumol, a natural product derived from hop
C. Gerhauser, A. Alt, E. Heiss, A. Gamal-Eldeen, K. Klimo, J. Knauft, et al. Molecular Cancer Therapeutics, 1 (2002), pp. 959–969
A comparison of the anticancer properties of isoxanthohumol and 8-prenylnaringenin using in vitro models of colon cancer
P. Allsopp, S. Possemiers, D. Campbell, C. Gill, I. Rowland Biofactors (2013) doi: 10.1002/biof.1084
Xanthohumol, prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells
E.C. Colgate, C.L. Miranda, J.F. Stevens, T.M. Bray, E. Ho Cancer Letters, 246 (1-2) (2007), pp. 201–209
Xanthohumol induces apoptosis in cultured 40-6 human colon cancer cells by activation of the death receptor- and mitochondrial pathway
L. Pan, H. Becker, C. Gerhauser Molecular Nutrition & Food Research, 49 (2005), pp. 837–843
Modulation of breast cancer cell urvival by aromatase inhibiting hop (Humulus lupulus L.) flavonoids
R. Monteiro, A. Faria, I. Azevedo, C. Calhau Journal of Steroid Biochemistry and Molecular Biology, 105 (2007), pp. 124–130
Effect of hop (Humulus lupulus L.) flavonoids on aromatase (estrogen synthase) activity
R. Monteiro, H. Becker, I. Azevedo, C. Calhau Journal of Agricultural and food Chemistry, 54 (2006), pp. 2938–2943
Antiinvasive effect of xanthohumol, a prenylated chalcone present in hops (Humulus lupulus L.) and beer
B. Vanhoecke, L. Derycke, V. Van Marck, H. Depypere, D. De Keukeleire, M. Bracke International Journal of Cancer, 117 (6) (2005), pp. 889–895
ANTI-INFLAMATORY
Xanthohumol treats inflammations by actively fighting cyclooxygenase and Lipoxygenase enzymes. It also neutralizes autoimmune diseases, cirrhosis of the liver and has antimicrobial activity, which is crucially important in disease prevention and infectious diseases treatment. Xanthohumol kills pathological bacteria, viruses and fungi – for instance, malaria-causing protozoa.
Scientific publications
Angiogenesis and inflammation signaling are targets of beer polyphenols on vascular cells
R. Negrao, R. Costa, D. Duarte, T.T. Gomes, M. Mendanha, L. Moura, et al. Journal of Cellular Biochemistry, 111 (2010), pp. 1270–1279
Cancer hemopreventive activity of xanthohumol, a natural product derived from hop
C. Gerhauser, A. Alt, E. Heiss, A. Gamal-Eldeen, K. Klimo, J. Knauft, et al. Molecular Cancer Therapeutics, 1 (2002), pp. 959–969
Differential antiinflammatory pathway by xanthohumol in IFN-gamma and LPS-activated macrophages
Y.C. Cho, H.J. Kim, Y.J. Kim, K.Y. Lee, H.J. Choi, I.S. Lee, B.Y. Kang International Immunopharmacology, 8 (4) (2008), pp. 567–573
Protective effect of xanthohumol on toxin-induced liver inflammation and fibrosis.
C. Dorn, J. Heilmann, C. Hellerbrand International Journal of Clinical and Experimental Pathology, 5 (1) (2012), pp. 29–36
A review of anti-infective and anti-inflammatory chalcones
Zdzisława Nowakowska European Journal of Medicinal Chemistry, 42(2), 125-137 (2007)
Xanthohumol Applications
Intensive research has found a very broad range of Xanthohumol applications, though the full range has not been fully discovered yet.
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